PCNA: structure, functions and interactions

alpha?synuclein structure, functions, and interactions

at present, when a clinical diagnosis of parkinson’s disease (pd) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. the diagnosis of pd in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation o...

Interactions : Structure Functions , Higher Twist

Effects of Multiple Structure-soil-structure Interactions Considering the Earthquake Waveform and Structures Elevation Effects

The simultaneous effects of soil and existing structures are known as the site-city interaction (structure-soil-structure). The impact of site-city interaction on structure behavior is effective. Thus, this interaction in some regions decreases the responses while increases in other areas. In addition, the site-city interaction of many parameters including the soil type, density rate, height of...

COMMENTARY DNA polymerase d/PCNA: actions and interactions

Recent work has shown that the proliferating cell nuclear antigen (PCNA) is an essential component for the replication of the eucaryotic virus, SV40, in a human cell extract. This is due to its interaction with a hitherto overlooked DNA polymerase (pol <5), and this discovery has brought these two proteins under the scrutiny of those working in the cell cycle, replication and DNA polymerase fie...

PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions

Proliferating cell nuclear antigen (PCNA) is an essential cofactor for DNA replication and repair, recruiting multiple proteins to their sites of action. We examined the effects of the PCNAS228I mutation that causes PCNA-associated DNA repair disorder (PARD). Cells from individuals affected by PARD are sensitive to the PCNA inhibitors T3 and T2AA, showing that the S228I mutation has consequence...